| PRESEASON | ||||
|---|---|---|---|---|
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Sunday, August 10 at 6::00 PM PST | -- | Minnesota Vikings | W 17 - 6 | 1 - 0 |
| Sunday, August 18 at 5:00 PM PST | -- | @ Houston Texans | L 9 - 20 | 1 - 1 |
| Saturday, August 26 at 1:00 PM PST | FOX | @ Denver Broncos | W 29 - 24 | 2 - 1 |
| Thursday, August 30 at 7:05 PM PST | -- | San Diego Chargers | W 35 - 3 | 3 - 1 |
| REGULAR SEASON | ||||
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Sunday, September 9 at 1:15 PM PST | FOX | @ Green Bay Packers | W 30 - 22 | 1 - 0 |
| Sunday, September 16 at 5:20 PM PST | NBC | Detroit Lions | W 27 - 19 | 2 - 0 |
| Sunday, September 23 at 10:00 AM PST | FOX | Minnesota Vikings | L 24 - 13 | 2 - 1 | Sunday, September 30 at 10:00 AM PST | FOX | @ New York Jets | W 34 - 0 | 3 - 1 |
| Sunday, October 7 at 1:15 PM PST | CBS | Buffalo Bills | W 45 - 3 | 4 - 1 | Sunday, October 14 at 1:15 PM PST | FOX | New York Giants | L 26 - 3 | 4 - 2 |
| Sunday, October 18 at 5:20 PM PST | NFL | Seattle Seahawks | W 13 - 6 | 5 - 2 |
| Monday, October 29 at 5:30 AM PST | ESPN | @ Arizona Cardinals | W 24 - 3 | 6 - 2 |
| Sunday, November 4 | BYE WEEK | |||
| Sunday, November 11 at 1:15 PM PST | FOX | St. Louis Rams | T 24 - 24 | 6 - 2 - 1 |
| Sunday, November 19 at 5:30 PM PST | ESPN | Chicago Bears | W 32 - 7 | 7 - 2 - 1 |
| Monday, November 25 at 1:15 PM PST | FOX | @ New Orleans Saints | W 31 - 21 | 8 - 2 - 1 |
| Sunday, December 2 at 10:00 AM PST | FOX | @ St. Louis Rams | L 13 - 16 | 8 - 3 - 1 |
| Sunday, December 9 at 1:05 PM PST | CBS | Miami Dolpins | W 27 - 13 | 9 - 3 - 1 | Thursday, December 16 at 5:20 PM PST | NBC | @ New England Patriots | W 41 - 34 | 10 - 3 - 1 |
| Sunday, December 23 at 1:15 PST | FOX | Seattle Seahawks | L 13 - 42 | 10 - 4 - 1 |
| Sunday, December 30 at 1:15 PM PST | FOX | Arizona Cardinals | W 27 - 13 | 11 - 4 - 1 |
| POST SEASON | ||||
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Saturday, January 12 at 5:15 PM PST | FOX | Green Bay Packers | W 45 - 31 | 1 - 0 |
| Sunday, January 20 at 12:00 PM PST | FOX | Atlanta Falcons | W 28 - 24 | 2 - 0 |
| Sunday, Feb 3 (Super Bowl XLVI) at 3:30 PM PST | CBS | Baltimore Ravens | L 31 - 34 | 2 - 1 |
| PRESEASON | ||||
|---|---|---|---|---|
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Friday, August 12 | -- | @ New Orleans | L 24 - 3 | 0 - 1 |
| Sunday, August 20 | -- | Oakland Raiders | W 17 - 3 | 1 - 1 |
| Saturday, August 2 | -- | Houston Texans | L 30 - 7 | 1 - 2 |
| Thursday, September 1 | -- | @ San Diego Chargers | W 20 - 17 | 2 - 2 |
| REGULAR SEASON | ||||
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Sunday, September 11 | FOX | Seattle Seahawks | W 33- 17 | 1 - 0 |
| Sunday, September 18 | FOX | Dallas Cowboys | L 27- 24 OT | 1 - 1 |
| Sunday, September 25 | FOX | @ Cincinnati Bengals | W 13- 8 | 2 - 1 | Sunday, October 2 | CBS | @ Philadelphia Eagles | W 24 - 23 | 3 - 1 |
| Sunday, October 9 | FOX | Tampa Bay Buccaneers | W 25- 19 | 4 - 1 |
| Sunday, October 16 | FOX | @ Detroit lions | W 20- 10 | 5 - 1 |
| Sunday, October 23 | BYE WEEK | |||
| Sunday, October 30 | CBS | Cleveland Browns | W 19 - 11 | 6 - 1 |
| Sunday, November 6 | FOX | @ Washington Redskins | W 27 - 20 | 7 - 1 |
| Sunday, November 13 | FOX | New York Giants | W 20 - 10 | 8 - 1 |
| Sunday, November 20 | FOX | Arizona Cardinals | W 23 - 7 | 9 - 1 |
| Thursday, November 24 | NFLN | @ Baltimore Ravens | L 16 - 6 | 9 - 2 |
| Sunday, December 4 | FOX | St. Louis Rams | W 26 - 0 | 10 - 2 |
| Sunday, December 11 | FOX | @ Arizona Cardinals | L 21 - 19 | 10 - 3 | Monday, December 19 | ESPN | Pittsburgh Steelers | W 20 - 3 | 11 - 3 |
| Saturday, December 24 | FOX | @ Seattle Seahawks | W 19 - 17 | 12 - 3 |
| Sunday, January 1 | FOX | @ St. Louis Rams | W 34 - 27 | 13 - 3 |
| POST SEASON | ||||
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Saturday, January 14 at 1:15 PM PST | FOX | New Orleans | W 33- 32 | 1 - 0 |
| Sunday, January 22 at 5:20 PM PST | NBC | New York Giants | L 20- 17 OT | 1 - 1 |
| PRESEASON | ||||
|---|---|---|---|---|
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Sunday, August 15 at 10:00 AM PST | CBS | @ Indianapolis Colts | W 37 - 17 | 1 - 0 |
| Sunday, August 22 at 5:00 PM PST | NBC | Minnesota Vikings | W 15 - 10 | 2 - 0 |
| Saturday, August 28 at 7:00 PM PST | CBS | @ Oakland Raiders | W 28 - 24 | 3 - 0 |
| Thursday, September 2 at 7:00 PM PST | CBS | San Diego Chargers | W 17 -14 | 4 - 0 |
| REGULAR SEASON | ||||
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Sunday, September 12 at 1:15 PM PST | FOX | @ Seattle Seahawks | L 31 - 6 | 0 - 1 |
| Monday, September 20 at 5:30 PM PST | ESPN, MNF | New Orleans Saints | L 25 - 22 | 0 - 2 |
| Sunday, September 26 at 10:00 AM PST | FOX | @ Kansas City Chiefs | L 31 - 10 | 0 - 3 | Sunday, October 3 at 10:00 AM PST | FOX | @ Atlanta Falcons | L 16 - 14 | 0 - 4 |
| Sunday, October 10 at 5:30 PM PST | NBC, SNF | Philadelphia Eagles | L 27 - 24 | 0 - 5 |
| Sunday, October 17 at 1:05 PM PST | CBS | Oakland Raiders | W 17 - 9 | 1 - 5 |
| Sunday, October 24 at 10:00 AM PST | FOX | @ Carolina Panthers | L 20 - 23 | 1 - 6 |
| Sunday, October 31 at 10:00 AM PST | CBS | @ London: vs. Denver | W 24 -16 | 2 - 6 |
| Sunday, November 7 | BYE WEEK | |||
| Sunday, November 14 at 1:15 PM PST | FOX | St. Louis Rams | W 23 - 20 | 3 - 6 |
| Sunday, November 21 at 1:05 PM PST | FOX | Tampa Bay Buccaneers | L 0 - 21 | 3 - 7 |
| Monday, November 29 at 5:30 PM PST | ESPN, MNF | @ Arizona Cardinals | W 27 - 6 | 4 - 7 |
| Sunday, December 5 at 10:00 AM PST | FOX | @Green Bay Packers | L 16 - 34 | 4 - 8 |
| Sunday, December 12 at 1:05 PM PST | FOX | Seattle Seahawks | W 40 - 21 | 5 - 8 | Thursday, December 16 at 5:30 PM PST | NFLN, TNF | @ San Diego Chargers | L 7 - 34 | 5 - 9 |
| Sunday, December 26 at 10:00 AM PST | FOX | @ St Louis Rams | L 17 - 25 | 5 - 10 |
| Sunday, January 2 at 1:15 PM PST | FOX | Arizona Cardinals | W 38 - 7 | 6 - 10 |
| PRESEASON | ||||
|---|---|---|---|---|
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Friday, August 14 at 7:00 PM PST | KPIX | Denver Broncos | W 17 - 16 | 1 - 0 |
| Saturday, August 22 at 5:15 PM PST | KPIX | Oakland Raiders | W 21 - 20 | 2 - 0 |
| Saturday, August 29 at 5:00 PM PST | KPIX | @ DallasCowboys | W 20 - 13 | 3 - 0 |
| Friday, September 4 at 7:00 PM PST | KPIX | @ San Diego Chargers | L 26 - 7 | 3 - 1 |
| REGULAR SEASON | ||||
| Date & Time (Pacific Standard Time) | Network | Opponent | Results | Record |
| Sunday, September 13 at 1:15 PM PST | FOX | @ Arizona Cardinals | W 20 - 16 | 1 - 0 |
| Sunday, September 20 at 1:05 PM PST | FOX | Seattle Seahawks | W 23 - 10 | 2 - 0 |
| Sunday, September 27 at 10:00 AM PST | FOX | @ Minnesota Vikings | L 27 - 20 | 2 -1 |
| Sunday, October 4 at 1:15 PM PST | FOX | St. Loius Rams | W 35 - 0 | 3 -1 |
| Sunday, October 11 at 1:05 PM PST | FOX | Atlanta Falcons | L 45 - 10 | 3 -2 |
| Sunday, October 18 | BYE WEEK | |||
| Sunday, October 25 at 10:00 AM PST | FOX | @ Houston Texans | L 24 - 21 | 3 - 3 |
| Sunday, November 1 at 10:00 AM PST | FOX | @ Indianapolis Colts | L 18 - 14 | 3 - 4 |
| Sunday, November 8 at 1:15 PM PST | CBS | Tennessee Titans | L 34 - 27 | 3 - 5 |
| Thursday, November 12 at 5:20 PM PST | NFL Network | Chicago Bears | W 10 - 6 | 4 - 5 |
| Sunday, November 22 at 10:00 AM PST | FOX | @ Green Bay Packers | L 30 - 24 | 4 - 6 |
| Sunday, November 29 at 1:05 PM PST | CBS | Jacksonville Jaguars | W 20 - 3 | 5 - 6 |
| Sunday, December 6 at 1:15 PM PST | FOX | @ Seattle Seahawks | L 20 - 17 | 5 - 7 |
| Monday, December 14 at 5:30 PM PST | ESPN | Arizona Cardinals | W 24 - 9 | 6 - 7 |
| Sunday, December 20 at 10:00 AM PST | FOX | @ Philadelphia Eagles | L 27 - 13 | 6 - 8 |
| Sunday, December 27 at 1:05 PM PST | FOX | Detroit Lions | W 20 - 6 | 7 - 8 |
| Sunday, January 3 at 10:00 AM PST | FOX | @ St. Louis Rams | W 28 - 6 | 8 - 8 |
| PRESEASON | |||
|---|---|---|---|
| Date & Time (Pacific Standard Time) | Opponent | Results | Record |
| Friday, August 8 at 7:00 PM PST | @ Oakland Raiders | L San Francisco 6 - Oakland 18 | 0 - 1 |
| Saturday, August 16 at 6:00 PM PST | Green Bay Packers | W San Francisco 34 - Green Bay 6 | 1 - 1 |
| Thursday, August 21 at 5:00 PM PST | @ Chicago Bears | W San Francisco 37 - Chicago 30 | 2 - 1 |
| Friday, August 29 at 7:00 PM PST | San Diego Chargers | L San Francisco 17 - San Diego 20 | 2 - 2 |
| REGULAR SEASON | |||
| Date & Time (Pacific Standard Time) | Opponent | Results | Record |
| Sunday, September 7 at 1:15 PM PST | Arizona Cardinals | L San Francisco 13 - Arizona 23 | 0 - 1 |
| Sunday, September 14 at 1:05 PM PST | @ Seattle Seahawks | W San Francisco 33 - Seattle 30 | 1 - 1 |
| Sunday, September 21 at 1:05 PM PST | Detroit Lions | W San Francisco 31 - Detroit 13 | 2 - 1 |
| Sunday, September 28 at 10:00 AM PST | @ New Orleans Saints | L San Francisco 17 - New Orleans 31 | 2 - 2 |
| Sunday, October 5 at 1:15 PM PST | New England Patriots | L San Francisco 21 - New England 30 | 2 - 3 |
| Sunday, October 12 at 1:15 PM PST | Philadelphia Eagles | L San Francisco 26 - Philadelphia 40 | 2 - 4 |
| Sunday, October 19 at 10:00 AM PST | @ New York Giants | L San Francisco 17 - New York 29 | 2 - 5 |
| Sunday, October 26 at 1:15 PM PST | Seattle Seahawks | L San Francisco 13 - Seattle 34 | 2 - 6 |
| Sunday, November 2 | Bye Week | ||
| Monday, November 10 at 5:30 PM PST | @ Arizona Cardinals | L San Francisco 24 - Arizona 29 | 2 - 7 |
| Sunday, November 16 at 1:05 PM PST | St. Louis Rams | W San Francisco 35 - St. Louis 16 | 3 - 7 |
| Sunday, November 23 at 12:00 PM PST | @ Dallas Cowboys | L San Francisco 22 - Dallas 35 | 3 - 8 |
| Sunday, November 30 at 10:00 AM PST | @ Buffalo Bills | W San Francisco 10 - Buffalo 3 | 4 - 8 |
| Sunday, December 7 at 1:05 PM PST | New York Jets | W San Francisco 24 - New York 14 | 5 - 8 |
| Sunday, December 14 at 10:00 AM PST | @ Miami Dolphins | L San Francisco 9 - Miami 14 | 5 - 9 |
| Sunday, December 21 at 10:00 AM PST | @ St. Louis Rams | W San Francisco 17 - St. Louis 16 | 6 - 9 |
| Sunday, December 28 at 1:15 PM PST | Washington Redskins | W San Francisco 27 - Washington 24 | 7 - 9 |
| PRESEASON | |||
|---|---|---|---|
| Date & Time (Pacific Standard Time) | Opponent | Results | Record |
| Monday, August 13 | Denver Broncos | L Denver 17 - San Francisco 13 | 0 - 1 |
| Saturday, August 18 | Oakland Raiders | W Oakland 21 - San Francisco 27 | 1 - 1 |
| Saturday,August 25 | @ Chicago Bears | L San Francisco 28 - Chicago 31 | 1 - 2 |
| Thursday, August 30 | @ San Diego Chargers | L San Francisco 13 - San Diego 16 | 1 - 3 |
| REGULAR SEASON | |||
| Date & Time (Pacific Standard Time) | Opponent | Results | Record |
| Monday, September 10 | Arizona Cardinals | W Arizona 17 - San Francisco 20 | 1 - 0 |
| Sunday, September 16 | @ St. Louis Rams | W St. Louis 16 - San Francisco 17 | 2 - 0 |
| Sunday, September 23 | @ Pittsburgh Steelers | L Pittsburgh 37 - San Francisco 16 | 2 - 1 |
| Sunday, September 30 | Seattle Seahawks | L San Francisco 3 - Seattle 23 | 2 - 2 |
| Sunday, October 7 | Baltimore Ravens | L San Francisco 7 - Baltimore 9 | 2 - 3 |
| Sunday, October 14 | Bye Week | ||
| Sunday, October 21 | @ New York Jets | L New York 33 - San Francisco 15 | 2 - 4 |
| Sunday, October 28 | New Orleans Saints | L San Francisco 10 - New Orleans 31 | 2 - 5 |
| Sunday, November 4 | @ Atlanta Falcons | L Atlanta 20 - San Francisco 16 | 2 - 6 |
| Monday, November 12 | @ Seattle Seahawks | L Seattle 24 - San Francisco 0 | 2 - 7 |
| Sunday, November 18 | St. Loius Rams | L San Francisco 9 - St. Loius 13 | 2 - 8 |
| Sunday, November 25 | @ Arizona Cardinals | W Arizona 31 - San Francisco 37 | 3 - 8 |
| Sunday, December 2 | @ Carolina Panthers | L Carolina 31 - San Francisco 14 | 3 - 9 |
| Sunday, December 6 | Minnesota Vikings | L San Francisco 7 - Minnesota 27 | 3 - 10 |
| Saturday, December 15 | Cincinnati Bengals | W San Francisco 20 - Cincinnati 13 | 4 - 10 |
| Sunday, December 23 | Tampa Bay Buccaneers | W San Francisco 21 - Tampa Bay 19 | 5 - 10 |
| Sunday, December 30 | @ Cleveland Browns | L Cleveland 20 - San Francisco 7 | 5 - 11 |