2008 Schedule | 2007 Schedule & Results
| PRESEASON | ||||
| Date | Opponent | Local Time | Pacific Time | Network |
| Friday, Aug. 8 | @ Oakland | 7:00 PM | CBS- 5 | |
| Saturday, Aug. 16 | Green Bay | 6:00 PM | CBS - 5 | |
| Thursday, August 21 | @ Chicago | 7:00 PM | 5:00 PM | FOX |
| Friday, August 29 | San Diego | 7:00 PM | CBS - 5 | |
| REGULAR SEASON | ||||
| Date | Opponent | Local Time | Pacific Time | Network |
| Sept. 7 | Arizona Cardinals | 1:15 PM | FOX | |
| Sept. 14 | @ Seattle Seahawks | 1:05 PM | FOX | |
| Sept. 21 | Detroit Lions | 1:05 PM | FOX | |
| Sept. 28 | @ New Orleans Saints | 12:00 PM | 10AM | FOX |
| Oct. 5 | New England Patriots | 1:15 PM | CBS | |
| Oct. 12 | Philadelphia Eagles | 1:15 PM | FOX | |
| Oct. 19 | @ New York Giants | 1:00 PM | 10AM | FOX |
| Oct. 26 | Seattle Seahawks | 1:15 PM | FOX | |
| Nov. 2 | BYE | |||
| Nov. 10 | @ Arizona Cardinals | 6:30 PM | 5:30 PM | ESPN |
| Nov. 16 | St. Louis Rams | 1:05 PM # | FOX | |
| Nov. 23 | @ Dallas Cowboys | 12:00 PM # | 10AM | FOX |
| Nov. 30 | @ Buffalo Bills | 1:00 PM # | 10AM | FOX |
| Dec. 7 | New York Jets | 1:05 PM # | CBS | |
| Dec. 14 | @ Miami Dolphins | 1:00 PM # | 10AM | FOX |
| Dec. 21 | @ St. Louis Rams | 12:00 PM # | 10AM | FOX |
| Dec. 28 | Washington Redskins | 1:15 PM # | FOX |
| 2007 Preseason | |||
| Date | Away Team | Home Team | W/L |
| August 13 | Denver 17 | San Francisco 13 | 0-1 |
| August 18 | Oakland 21 | San Francisco 27 | 1-1 |
| August 25 | San Francisco 28 | Chicago 31 | 1-2 |
| August 30 | San Francisco 13 | San Diego 16 | 1-3 |
| 2007 Regular Season | |||
| September 10 | Arizona 17 | San Francisco 20 | 1-0 |
| September 16 | San Francisco 17 | St. Louis 16 | 2-0 |
| September 23 | San Francisco 16 | Pittsburgh 37 | 2-1 |
| September 30 | Seattle 23 | San Francisco 3 | 2-2 |
| October 7 | Baltimore 9 | San Francisco 7 | 2-3 |
| October 14 | Bye Week | ||
| October 21 | San Francisco 15 | New York 33 | 2-4 |
| October 28 | New Orleans 31 | San Francisco 10 | 2-5 |
| November 4 | San Francisco 16 | Atlanta 20 | 2-6 |
| November 12 | San Francisco 0 | Seattle 24 | 2-7 |
| November 18 | St. Loius 13 | San Francisco 9 | 2-8 |
| November 25 | San Francisco 37 | Arizona 31 | 3-8 |
| December 2 | San Francisco 14 | Carolina 31 | 3-9 |
| December 6 | Minnesota 27 | San Francisco 7 | 3-10 |
| December 15 | Cincinnati 13 | San Francisco 20 | 4-10 |
| December 23 | Tampa Bay 19 | San Francisco 21 | 5-10 |
| December 30 | San Francisco 7 | Cleveland 20 | 5-11 |